Web app error tracking startup Exceptional has acquired fellow error tracking application and competitor, Airbrake, from web design and development company thoughtbot. Financial terms of the acquisition were not released. Simply put, Airbrake tracks errors in web apps. The app will collects errors generated by a variety of applications, and aggregates the results for review by developers. Airbrake's service is used by a number of high-profile companies including Groupon, eBay Square and AT&T.
(Reuters) ? Los Angeles Clippers guard Chauncey Billups was helped off the court after injuring his left Achilles during his team's overtime victory over the Orlando Magic on Monday.
Billups took an awkward step with no one around him and immediately fell to the floor midway through the fourth quarter.
The Clippers, off to a 15-7 start and the lead in the Pacific Division, will send the guard for a scan on Tuesday.
"I'm hoping it's not that bad," Clippers point guard Chris Paul told reporters. "We know we have to lift up the team and pick up what we'll miss without him being on the court."
In the Eastern Conference, New York forward Carmelo Anthony also had to exit early after suffering a right groin injury.
Anthony, voted a starter for this month's All Star game, hurt his right groin while throwing an alley-oop during the first quarter and hobbled off the court. The Knicks beat Utah 99-88.
The team is calling the injury a strain and said Anthony is day-to-day and will be re-evaluated on Tuesday.
The Knicks are already without forward Amar'e Stoudemire, who is on an indefinite leave of absence after the death of his brother.
(Writing by Jahmal Corner in Los Angeles. Editing by Patrick Johnston)
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Whole-genome sequencing of 2011 E. coli outbreaks in Europe provides new insightPublic release date: 6-Feb-2012 [ | E-mail | Share ]
Contact: Todd Datz tdatz@hsph.harvard.edu 617-432-8413 Harvard School of Public Health
Boston, MA Using whole-genome sequencing, a team led by researchers from Harvard School of Public Health (HSPH) and the Broad Institute has traced the path of the E. coli outbreak that sickened thousands and killed over 50 people in Germany in summer 2011 and also caused a smaller outbreak in France. It is one of the first uses of genome sequencing to study the dynamics of a food-borne outbreak and provides further evidence that genomic tools can be used to investigate future outbreaks and provide greater insight into the emergence and spread of infectious diseases.
The study, conducted in collaboration with groups at the Pasteur Institute in France, Assistance Publique-Hpitaux de Paris, and Statens Serum Institut in Denmark, appears on February 6, 2012 in an advance online edition of Proceedings of the National Academy of Sciences.
"A genome contains the record of a strain's evolutionary history, so by looking at the differences between the genomes of multiple bacteria from an outbreak we can get really useful clues about what happened in the outbreak. In this way, tracking outbreaks is like detective work, and this approach will be a powerful tool in trying to understand future outbreaks," said lead author Yonatan Grad, a research fellow in the Center for Communicable Disease Dynamics, Department of Epidemiology at HSPH and infectious disease physician at Brigham and Women's Hospital in Boston.
"This work is a testament to the power of genome sequencing and analysis to shed light on the mechanisms that drive disease outbreaks," said co-senior author Deborah Hung, a core faculty member at the Broad Institute, an assistant professor at Massachusetts General Hospital and Harvard Medical School, and an infectious disease physician at Brigham and Women's Hospital. "We can see things that we simply couldn't see before, and that holds promise for improving public health."
The outbreak in Germany, which was caused by the strain E. coli O104:H4, led to around 4,000 cases of bloody diarrhea, 850 cases of hemolytic uremic syndrome (HUS), which can lead to kidney failure, and over 50 deaths. The source of the outbreak was traced to sprouts from an organic farm in Germany. In France, where 15 people were sickened with bloody diarrhea that progressed to HUS in nine people, the source of the outbreak was sprouts, germinated from seeds purchased at a garden retailer, that were served at a children's community center buffet. European investigators, using traditional epidemiological methods, traced the outbreaks to a shipment of seeds from Egypt that arrived in Germany in December 2009.
The researchers, led by Grad and senior authors Hung and William Hanage, associate professor of epidemiology at HSPH, analyzed isolates of E. coli bacteria from both the German and French outbreaks. Based on conventional molecular epidemiological analysis, the E. coli strains from the outbreaks in Germany and France appear identical.
However, by harnessing the Broad's expertise in whole-genome sequencing and analysis, the researchers were able to determine that there were small, but measurable, differences among the isolates. They made two surprising findings: All the strains connected to the larger German outbreak were found to be nearly identical, while the strains in France showed greater diversity; and the German isolates appeared to be a subset of the diversity seen in the French isolates.
"If genomes have fewer differences than we expect, like the German outbreak, it suggests that the outbreak might have passed through a bottleneck. A bottleneck might be something like disinfection procedures that killed most but not all of the bugs, or maybe passage through a single infected individual," said Hanage.
Another hypothesis offered by the researchers is that there was uneven distribution of diversity in the original shipment of contaminated seeds.
As costs for genomic sequencing decline, these tools, combined with traditional epidemiological techniques, can provide greater insight into the emergence and spread of infectious diseases and will help guide preventive public health measures in the future.
###
Support for this study was provided by the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health (NIH); Infectious Disease Program of the Broad Institute; NIH's National Institute of General Medical Sciences Models of Infectious Disease Agent Study (MIDAS) Award; Danish Council for Strategic Research; Institut de Veille Sanitaire.
"Genomic Epidemiology of the Escherichia coli O104:H4 Outbreaks in Europe, 2011," Yonatan H. Grad, Marc Lipsitch, Michael Feldgarden, Harindra M. Arachchi, Gustavo C. Cerqueira, Michael FitzGerald, Paul Godfrey, Brian J. Haas, Cheryl Murphy, Carsetn Russ, Sean Sykes, Bruce J. Walker, Jennifer R. Wortman, Sarah Young, Qiandong Zeng, Amr Abouelleil, James Bochicchio, Sara Chauvin, Timothy DeSmet, Sharvari Gujja, Caryn McCowan, Anna Montmayeur, Scott Stellman, Jakob Frimodt-Moller, Andreas M. Petersen, Carsten Struve, Karen A. Krogfelt, Edouard Bingen, Francois-Xavier Weill, Eric S. Lander, Chad Nusbaum, Bruce W. Birren, Deborah T. Hung, William P. Hanage, Proceedings of the National Academy of Sciences, online February 6, 2012
Visit the HSPH website for the latest news, press releases and multimedia offerings.
About Harvard School of Public Health
Harvard School of Public Health is dedicated to advancing the public's health through learning, discovery and communication. More than 400 faculty members are engaged in teaching and training the 1,000-plus student body in a broad spectrum of disciplines crucial to the health and well being of individuals and populations around the world. Programs and projects range from the molecular biology of AIDS vaccines to the epidemiology of cancer; from risk analysis to violence prevention; from maternal and children's health to quality of care measurement; from health care management to international health and human rights. For more information on the school visit www.hsph.harvard.edu.
HSPH on Twitter: http://twitter.com/HarvardHSPH
HSPH on Facebook: http://www.facebook.com/harvardpublichealth
HSPH on YouTube: http://www.youtube.com/user/HarvardPublicHealth
HSPH home page: http://www.hsph.harvard.edu
About the Broad Institute of MIT and Harvard
The Eli and Edythe L. Broad Institute of MIT and Harvard was founded in 2003 to empower this generation of creative scientists to transform medicine with new genome-based knowledge. The Broad Institute seeks to describe all the molecular components of life and their connections; discover the molecular basis of major human diseases; develop effective new approaches to diagnostics and therapeutics; and disseminate discoveries, tools, methods and data openly to the entire scientific community. Founded by MIT, Harvard and its affiliated hospitals, and the visionary Los Angeles philanthropists Eli and Edythe L. Broad, the Broad Institute includes faculty, professional staff and students from throughout the MIT and Harvard biomedical research communities and beyond, with collaborations spanning over a hundred private and public institutions in more than 40 countries worldwide. For further information about the Broad Institute, go to www.broadinstitute.org.
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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Whole-genome sequencing of 2011 E. coli outbreaks in Europe provides new insightPublic release date: 6-Feb-2012 [ | E-mail | Share ]
Contact: Todd Datz tdatz@hsph.harvard.edu 617-432-8413 Harvard School of Public Health
Boston, MA Using whole-genome sequencing, a team led by researchers from Harvard School of Public Health (HSPH) and the Broad Institute has traced the path of the E. coli outbreak that sickened thousands and killed over 50 people in Germany in summer 2011 and also caused a smaller outbreak in France. It is one of the first uses of genome sequencing to study the dynamics of a food-borne outbreak and provides further evidence that genomic tools can be used to investigate future outbreaks and provide greater insight into the emergence and spread of infectious diseases.
The study, conducted in collaboration with groups at the Pasteur Institute in France, Assistance Publique-Hpitaux de Paris, and Statens Serum Institut in Denmark, appears on February 6, 2012 in an advance online edition of Proceedings of the National Academy of Sciences.
"A genome contains the record of a strain's evolutionary history, so by looking at the differences between the genomes of multiple bacteria from an outbreak we can get really useful clues about what happened in the outbreak. In this way, tracking outbreaks is like detective work, and this approach will be a powerful tool in trying to understand future outbreaks," said lead author Yonatan Grad, a research fellow in the Center for Communicable Disease Dynamics, Department of Epidemiology at HSPH and infectious disease physician at Brigham and Women's Hospital in Boston.
"This work is a testament to the power of genome sequencing and analysis to shed light on the mechanisms that drive disease outbreaks," said co-senior author Deborah Hung, a core faculty member at the Broad Institute, an assistant professor at Massachusetts General Hospital and Harvard Medical School, and an infectious disease physician at Brigham and Women's Hospital. "We can see things that we simply couldn't see before, and that holds promise for improving public health."
The outbreak in Germany, which was caused by the strain E. coli O104:H4, led to around 4,000 cases of bloody diarrhea, 850 cases of hemolytic uremic syndrome (HUS), which can lead to kidney failure, and over 50 deaths. The source of the outbreak was traced to sprouts from an organic farm in Germany. In France, where 15 people were sickened with bloody diarrhea that progressed to HUS in nine people, the source of the outbreak was sprouts, germinated from seeds purchased at a garden retailer, that were served at a children's community center buffet. European investigators, using traditional epidemiological methods, traced the outbreaks to a shipment of seeds from Egypt that arrived in Germany in December 2009.
The researchers, led by Grad and senior authors Hung and William Hanage, associate professor of epidemiology at HSPH, analyzed isolates of E. coli bacteria from both the German and French outbreaks. Based on conventional molecular epidemiological analysis, the E. coli strains from the outbreaks in Germany and France appear identical.
However, by harnessing the Broad's expertise in whole-genome sequencing and analysis, the researchers were able to determine that there were small, but measurable, differences among the isolates. They made two surprising findings: All the strains connected to the larger German outbreak were found to be nearly identical, while the strains in France showed greater diversity; and the German isolates appeared to be a subset of the diversity seen in the French isolates.
"If genomes have fewer differences than we expect, like the German outbreak, it suggests that the outbreak might have passed through a bottleneck. A bottleneck might be something like disinfection procedures that killed most but not all of the bugs, or maybe passage through a single infected individual," said Hanage.
Another hypothesis offered by the researchers is that there was uneven distribution of diversity in the original shipment of contaminated seeds.
As costs for genomic sequencing decline, these tools, combined with traditional epidemiological techniques, can provide greater insight into the emergence and spread of infectious diseases and will help guide preventive public health measures in the future.
###
Support for this study was provided by the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health (NIH); Infectious Disease Program of the Broad Institute; NIH's National Institute of General Medical Sciences Models of Infectious Disease Agent Study (MIDAS) Award; Danish Council for Strategic Research; Institut de Veille Sanitaire.
"Genomic Epidemiology of the Escherichia coli O104:H4 Outbreaks in Europe, 2011," Yonatan H. Grad, Marc Lipsitch, Michael Feldgarden, Harindra M. Arachchi, Gustavo C. Cerqueira, Michael FitzGerald, Paul Godfrey, Brian J. Haas, Cheryl Murphy, Carsetn Russ, Sean Sykes, Bruce J. Walker, Jennifer R. Wortman, Sarah Young, Qiandong Zeng, Amr Abouelleil, James Bochicchio, Sara Chauvin, Timothy DeSmet, Sharvari Gujja, Caryn McCowan, Anna Montmayeur, Scott Stellman, Jakob Frimodt-Moller, Andreas M. Petersen, Carsten Struve, Karen A. Krogfelt, Edouard Bingen, Francois-Xavier Weill, Eric S. Lander, Chad Nusbaum, Bruce W. Birren, Deborah T. Hung, William P. Hanage, Proceedings of the National Academy of Sciences, online February 6, 2012
Visit the HSPH website for the latest news, press releases and multimedia offerings.
About Harvard School of Public Health
Harvard School of Public Health is dedicated to advancing the public's health through learning, discovery and communication. More than 400 faculty members are engaged in teaching and training the 1,000-plus student body in a broad spectrum of disciplines crucial to the health and well being of individuals and populations around the world. Programs and projects range from the molecular biology of AIDS vaccines to the epidemiology of cancer; from risk analysis to violence prevention; from maternal and children's health to quality of care measurement; from health care management to international health and human rights. For more information on the school visit www.hsph.harvard.edu.
HSPH on Twitter: http://twitter.com/HarvardHSPH
HSPH on Facebook: http://www.facebook.com/harvardpublichealth
HSPH on YouTube: http://www.youtube.com/user/HarvardPublicHealth
HSPH home page: http://www.hsph.harvard.edu
About the Broad Institute of MIT and Harvard
The Eli and Edythe L. Broad Institute of MIT and Harvard was founded in 2003 to empower this generation of creative scientists to transform medicine with new genome-based knowledge. The Broad Institute seeks to describe all the molecular components of life and their connections; discover the molecular basis of major human diseases; develop effective new approaches to diagnostics and therapeutics; and disseminate discoveries, tools, methods and data openly to the entire scientific community. Founded by MIT, Harvard and its affiliated hospitals, and the visionary Los Angeles philanthropists Eli and Edythe L. Broad, the Broad Institute includes faculty, professional staff and students from throughout the MIT and Harvard biomedical research communities and beyond, with collaborations spanning over a hundred private and public institutions in more than 40 countries worldwide. For further information about the Broad Institute, go to www.broadinstitute.org.
[ | E-mail | Share ]
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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
The foremost benefit in building a customized home is that you get a house that meets your preferences perfectly, both in terms of purpose and value.
Nowadays, most spec homes are built with ?builder?s grade? materials to reduce the cost of the structure. However, these kinds of products have short life spans and the selections of house layouts and features are often restricted. Customized home building on the other hand gives you vast alternatives and lets you choose what to place and where. You would be able to decide the layout of your house, the floor size, colors of the walls, cabinet and flooring designs as well as artificial lighting and landscaping. Practically, the possibilities are endless as long as you have the right custom builders to consult and to help you construct a house that will match your preferences and necessities.
Nevertheless, building a fully customized home is costly. Exceptional features and products are not sold ?builder grade? price box in home improvement shops. This way you can assume to expend 2-3 times more per square foot structure costs of assembling a fully customized house.
Building a semi customized home generally proposes several house layouts and floor plans to choose from. Also, you may choose from cabinets, flooring, appliances, lighting and spot lighting. Often, the flexibility depends on the budget allocation. For instance, a developer may offer a stipend of $ 2,000 budget for kitchen appliances and you will choose what will be installed in your kitchen. If you decide to buy devices that exceed the allowance, of course you have to pay the extra costs of it.
Even if you?ve hired a great designer and builder, you have to work and decide on many things. Prepare to spend time in home improvement centers, bathroom and kitchen flooring stores, lighting stores, etc. You will have to make decisions on various features of your house and you would not be able to do this if you would buy a spec house.
Nowadays, most spec homes are built with ?builder?s grade? materials to reduce the cost of the structure. However, these kinds of products have short life spans and the selections of house layouts and features are often restricted. Customized home building on the other hand gives you vast alternatives and lets you choose what to place and where. You would be able to decide the layout of your house, the floor size, colors of the walls, cabinet and flooring designs as well as artificial lighting and landscaping. Practically, the possibilities are endless as long as you have the right custom builders to consult and to help you construct a house that will match your preferences and necessities.
The foremost benefit in building a customized home is that you get a house that meets your preferences perfectly, both in terms of purpose and value.
This will be another short diary. ?If this has been shared on Kos in another diary already, I'll delete my diary. ?
One silver lining in all of this is that, for many of us, the true Susan G. Komen (SGK) organization has been laid bare. It's ideology, theology (who knew), and the agenda of those who now steer the future of this organization. ?(Ari Fleischer, are you kidding me?)
Another silver lining is that Planned Parenthood (PP) has been thrust into the national spotlight, and the national dialogue. ?Millions of men and women, from all walks of religion, political beliefs and personal ideologies, came together and raised millions of dollars for Planned Parenthood. ?What has also been revealed is that Planned Parenthood is NOT, and never was, an "abortion factory." ?Now, right wing fundies will always believe what they want, even when those beliefs have no basis in reality or fact. ?But many other people learned a lot of things this week, important things - about what SGK is not and what PP is, who they are, what they do, and how many millions of women rely on their services to provide the most basic of healthcare. ?
So as I always try to believe, there is ALWAYS a silver lining...
This is the face of breast cancer. ?It is the best, frankest and most honest response to Komen that I've seen in the many days since Komengate exploded. ?This woman is unbelievably brave. She honest and frank, and she truly exposes what breast cancer is. ?She also exposes what breast cancer is NOT.
The video is graphic. ?After many years on Kos, I STILL don't know how to embed video/pictures, so here's the link to one of the best responses I've ever seen to Komengate.
I'd love for this video to go viral. ?I'm posting on Facebook. I'm tweeting it. I first saw it because of today's Crooks and Liars email. ?
If you are so inclined, please pass it on.
On a personal note, I am now a monthly contributor to Planned Parenthood. I should ?have done this before, but it is better late than never. ?I, like many, just never realized the depth of services that PP provides, nor the extent to which so many women rely on them. ?I am fortune. Millions of women are not. ?I owe it to them to pay it forward ...
(I will be out all afternoon so if I need to take this diary down after all, it won't be until much later.)
Embracing Home is a place to get inspired... Make room for joy, love, laughter and peace in your life.
When it?s time for the family to get together you want to make sure to have games planned ahead of time that will be fun for everyone involved. If you?ve ever had boring or stressful ?family time? then you know that it?s best to plan ahead of time to make sure that it turns out to be a success. Here in this article I?ll give you a few family game night ideas that I?m certain your whole family will love.
?Rain drops on roses?.? That?s the way one of my favorite songs starts. As I was thinking up family game night ideas, I wanted to add a positive and joyful touch. So I thought of getting elements from several different games that I?ve played in my life and put it all together. The basis of this family game idea is to get to know what each family member?s favorite things are. That way it?s not just a game, but an opportunity to get to know each person on a deeper level. Of course you can always watch children?s and family entertainment movies but games are so much more interactive.
This is how you play:
One of the family members will think of his or her favorite item. ( At the end of this post I have a list of favorite ideas that can be asked.) Players take turns asking questions to that family member and he or she can only answer yes or no to the questions. Each time a player asks a question he or she also gets to guess what the favorite thing is. If the person asking the question doesn?t guess right thing, anyone else can guess the favorite thing. Everyone takes turns asking the questions. You can also have a talking stick that can be passed around the circle to indicate who is now asking the question. The first person that guesses the favorite thing correctly wins a token. At the end of the game, the person with the most tokens wins.
Another Variance of this Game
You can play win lose or draw with it. To play this way there should be a stack of cards with the favorite thing written on each one. The first person that will to draw picks out a ?favorite card?, reads what is asked to the group, and starts drawing on a white board (or large sheet of paper) what their favorite thing is. All of the other players gather around and shout out their guesses while the person is drawing. The first person that guesses correctly wins a point and gets to keep a token to keep track of how many correct guesses he or she had. The person drawing picks out the next card. Each player gets to pick out 3 or 4 cards (depending on the amount of players). In the end, the person with the most correct guesses, wins a prize. If you go through 20 of the following questions, this game will last about an hour. You don?t have to use all of the questions and if someone feels the questioon is too hard, they can choose another one. It?s more about everyone having a fun time.
? Your favorite sweet food
? Your favorite beverage
? Your favorite fast food sandwich
? Your favorite lunch plate
? Your favorite type of ice cream
? Your favorite fruit
? Your favorite vegetable
? Your favorite birthday party that you?ve ever had
? Your favorite shopping center to go to
? Your favorite restaurant
? Your favorite color
? Your favorite comedy movie
? Your favorite romantic movie
? Your favorite adventure movie
? Your favorite drama movie
? Your all time favorite movie
? Your favorite TV show
? Your favorite cartoon character
? Your favorite actor/actress
? Your favorite animal
? Your favorite thing to do
? Your favorite Bible hero ? other than Jesus
? Your favorite Bible story
? Your favorite Bible verse
? Your favorite toy when you were little
? Your favorite flower
? Your favorite (physical) part of yourself. (The part that you think is most good looking. This can be eyes, hair, etc.)
? Your favorite place to go on vacation
? Your favorite book
For more ideas, check out this article family bonding activities that you can do.
I hope you enjoyed these family game night ideas.
Blessings always,
Eren Mckay
P.S. You can find out about the Embracing Home Newsletter by clicking on this link.
Web app error tracking startup Exceptional has acquired fellow error tracking application and competitor, Airbrake, from web design and development company thoughtbot. Financial terms of the acquisition were not released. Simply put, Airbrake tracks errors in web apps. The app will collects errors generated by a variety of applications, and aggregates the results for review by developers. Airbrake's service is used by a number of high-profile companies including Groupon, eBay Square and AT&T.
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Public release date: 6-Feb-2012
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I hope you enjoyed these family game night ideas.